Interferon regulatory factor signaling in autoimmune disease
نویسندگان
چکیده
منابع مشابه
Interferon- : A Key Factor in Autoimmune Disease?
METHODS. Eleven patients with refractory uveitis, and 13 healthy individuals were enrolled. The number of circulating plasmacytoid dendritic cells (pDCs) and their capacity to produce IFNin culture on stimulation with synthetic oligodinucleotides containing the CpG-motif were studied. Peripheral blood CD4 T-cell phenotype and activation status were evaluated by flow cytometry at 0, 2, and 8 wee...
متن کاملIRF4 (interferon regulatory factor 4)
Other names: IRF-4; NF-EM5; LSIRF (lymphocytespecific interferon regulatory factor); MUM1 (multiple myeloma oncogene 1) HGNC (Hugo): IRF4 Location: 6p25.3 Local order: IRF4 is located on chromosome 6 at the telomeric extremity of the short arm, and lies between the DUSP22 (dual specificity phosphatase 22) and EXOC2 (exocyst complex component 2) genes. Note: IRF4 belongs to the IRF (interferon r...
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Type I interferons (IFN-I) broadly control innate immunity and are typically transcriptionally induced by Interferon Regulatory Factors (IRFs) following stimulation of pattern recognition receptors within the cytosol of host cells. For bacterial infection, IFN-I signaling can result in widely variant responses, in some cases contributing to the pathogenesis of disease while in others contributi...
متن کاملAutoimmune manifestations in human myelodysplasia: a positive correlation with interferon regulatory factor-1 (IRF-1) expression.
BACKGROUND Patients with myelodysplasia may have autoimmune manifestations (AIM). Interferon regulatory factor-1 (IRF-1) is a transcription factor involved in interferon signalling, leukaemogenesis, and the development of the immune system. OBJECTIVES To determine whether IRF-1 is implicated in the pathophysiology of AIM in myelodysplasia. METHODS 14 patients with myelodysplasia were studie...
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Interferon regulatory factor-1 (IRF-1) is a transcription factor that regulates interferon-induced genes and type I interferons. Recently, studies of IRF-l-deficient mice have revealed that IRF-I regulates the induction of molecules that play important roles in inflammation, such as inducible nitric oxide synthase (iNOS) and interleukin-l beta-converting enzyme (ICE). To study the role of IRF-1...
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ژورنال
عنوان ژورنال: Cytokine
سال: 2017
ISSN: 1043-4666
DOI: 10.1016/j.cyto.2017.02.006